Division of Intramural Research News Features 2008 - 2009
2009
November 2009: Taking Aim At Trypanosomes
 The NIH Chemical Genomics Center (NCGC), administered by the National Human Genome Research Institute, is training its leading-edge technology on two ancient scourges: Chagas disease and African sleeping sickness. In two studies published Nov. 11 in the online edition of the Journal of Medicinal Chemistry, NCGC researchers, along with collaborators from the University of California-San Francisco, identified a group of compounds with the potential to inhibit parasitic Trypanosoma microbes and unveiled a public dataset that will aid the entire field of drug discovery. ( more)
October 2009: NHGRI Researchers Create New Database of Drug-Metabolizing Enzymes
 In their quest to find new and better drugs, researchers weigh many factors. Among the most important factors is how a compound will interact with a family of liver enzymes, known as the cytochrome P450s (CYPs), that play an essential role in drug metabolism. ( more)
September 2009: Prepublication Data Sharing: The Toronto Statement
 International experts have updated guidelines for the rapid release of genomics data and proposed extending the prepublication release principles to other biological data sets. Two NHGRI researchers are among the authors of an Opinion article about rapid data release published, now in the journal Nature.( more)
April 2009: Novel Gene Found Critical for Regeneration in Zebrafish
 NHGRI researchers have identified a gene that plays a crucial role in the ability of zebrafish to regenerate vibration-detecting hair cells, like those in the human inner ear. Named phoenix, the gene may help unlock the secrets of these amazing regenerative powers and the possibility of restoring human hearing and balance. ( more)
April 2009: Familial Lung Cancer Gene Located
 A consortium that includes scientists from the National Human Genome Research Institute has identified a gene associated with an increased susceptibility for lung cancer in members of families with a history of the disease. The new finding is reported in the April 15, 2009 issue of the journal Clinical Cancer Research. ( more)
March 2009: NHGRI Research Helps to Demystify Dyslexia
 Dyslexia is one of the world's most common learning disorders. NHGRI researchers are helping to open a new window on this complex condition with a new genomic discovery reported in the journal PLoS Genetics. ( more)
January 2009: Darwin @200
 February 12, 2009, marks the 200th birthday of Charles Darwin (1809-1882) and the 150 th year since publication of his seminal work, On the Origin of Species. The National Human Genome Research Institute will observe Darwin's life and accomplishments at events at the NIH's Bethesda campus and at the Smithsonian Institution's National Museum of Natural History. ( more)
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2008
December 2008: Two NHGRI Intramural Investigators Selected for Presidential Award
 Two National Human Genome Research Institute (NHGRI) investigators — cancer geneticist Daphne W. Bell, Ph.D., investigator in the Cancer Genetics Branch, and bioinformatician Elliott Margulies, Ph.D., investigator in the Genome Technology Branch — have received the 2007 Presidential Early Career Award for Scientists and Engineers (PECASE). They are among 12 PECASE awardees supported by the National Institutes of Health (NIH) and the only NIH intramural investigators among this year's awardees. The awards were presented at a White House ceremony on Dec. 19, 2008. ( more)
November 2008: Chemical Genomics Screen Uncovers Clues to Fat Storage
In a study published in the Nov. 25, 2008 issue of PLoS Biology, a team from the National Institute of Diabetes and Digestive and Kidney Diseases, the University of Maryland, Baltimore, and the NIH Chemical Genomics Center — an affiliated center with NHGRI — identified a cellular pathway that regulates fat storage and showed that interrupting the pathway boosts the amount of fat stored by human cells.
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May 2008: NHGRI Research Reveals Humans Share a Common Set of Skin Microbes
 A team of researchers from the National Institutes of Health (NIH), led by Julie Segre, Ph.D., a senior investigator in the Genetics and Molecular Biology Branch at the National Human Genome Research Institute (NHGRI), has found that healthy humans share a common set of microorganisms living in and on the area of skin around the inner elbow, an area where atopic dermatitis (eczema) is known to develop, research published a study in the online issue of Genome Research. ( more)
April 2008: Dr. Pamela Schwartzberg Inducted into Association of American Physicions
 Pamela Schwartzberg, M.D., Ph.D., senior investigator in the Genetic Disease Research Branch, is a 2008 inductee into the Association of American Physicians (AAP). She was inducted at the AAP's annual meeting in Chicago, April 25-27, 2008. ( more)
February 2008: Finding What's Toxic Fast
 Chemical compounds — from household cleaners to pesticides — require testing to reveal hazards that they may pose to human health. An effort now underway by three collaborating federal research groups seeks to rapidly evaluate larger numbers of chemicals for risks to humans while reducing the role of laboratory animals in regulatory testing. ( more)
January 2008: Pam Schwartzberg Wins AAI Investigator Award
Pamela L. Schwartzberg, M.D., Ph.D., senior investigator and head of the Cell Signaling Section of the Genetic Disease Research Branch of the National Human Genome Research Institute (NHGRI), will receive the AAI-BD Biosciences Investigator Award from the American Association of Immunologists (AAI). ( more)
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