While predisposition to some cancers is hereditary, many others result from genetic changes that occur throughout life. Using the techniques of modern molecular biology, researchers in the Cancer Genetics Branch (CGB) seek to define the genetic changes that lead to the initiation and progression of cancer. The CGB is involved in a range of experimental studies including: the identification of inherited mutations predisposing family members to malignant melanoma, prostate and breast cancer; identification of genes involved in the development of malignant characteristics in cancer cells, such as metastasis and drug resistance; and, the development and application of technologies for whole-genome scanning of genetic variation and gene expression (using microarray technology).

Principal Investigators

Jeffrey M. Trent, Ph.D.
Scientific Director, NHGRI Division Of Intramural Research
Senior Investigator and Chief, Cancer Genetics Branch

Olli-P. Kallioniemi, M.D., Ph.D.
Senior Investigator, Cancer Genetics Branch
Head, Translational Genomics Section

Paul S. Meltzer, M.D., Ph.D.
Senior Investigator, Cancer Genetics Branch
Head, Molecular Cytogenetics Section

John D. Carpten, Ph.D.
Investigator, Cancer Genetics Branch
Head, Cancer Genomics Section